The G-patch protein Spp2 couples the spliceosome-stimulated ATPase activity of the DEAH-box protein Prp2 to catalytic activation of the spliceosome

Structural rearrangement of the activated spliceosome (B(act)) to yield a catalytically active complex (B*) is mediated by the DEAH-box NTPase Prp2 in cooperation with the G-patch protein Spp2. However, how the energy of ATP hydrolysis by Prp2 is coupled to mechanical work and what role Spp2 plays i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genes Dev
Prif Awduron: Warkocki, Zbigniew, Schneider, Cornelius, Mozaffari-Jovin, Sina, Schmitzová, Jana, Höbartner, Claudia, Fabrizio, Patrizia, Lührmann, Reinhard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2015
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285774/
https://ncbi.nlm.nih.gov/pubmed/25561498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.253070.114
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