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Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre

RNA-structural elements play key roles in pre-mRNA splicing catalysis; yet, the formation of catalytically competent RNA structures requires the assistance of spliceosomal proteins. We show that the S. cerevisiae Cwc2 protein functions prior to step 1 of splicing, and it is not required for the Prp2...

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Detalhes bibliográficos
Main Authors: Rasche, Nicolas, Dybkov, Olexandr, Schmitzová, Jana, Akyildiz, Berktan, Fabrizio, Patrizia, Lührmann, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321175/
https://ncbi.nlm.nih.gov/pubmed/22246180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.502
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