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Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre
RNA-structural elements play key roles in pre-mRNA splicing catalysis; yet, the formation of catalytically competent RNA structures requires the assistance of spliceosomal proteins. We show that the S. cerevisiae Cwc2 protein functions prior to step 1 of splicing, and it is not required for the Prp2...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3321175/ https://ncbi.nlm.nih.gov/pubmed/22246180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.502 |
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