Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein

The yeast splicing factor Cwc2 contacts several catalytically important RNA elements in the active spliceosome, suggesting that Cwc2 is involved in determining their spatial arrangement at the spliceosome's catalytic centre. We have determined the crystal structure of the Cwc2 functional core,...

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Bibliografiska uppgifter
Huvudupphovsmän: Schmitzová, Jana, Rasche, Nicolas, Dybkov, Olexander, Kramer, Katharina, Fabrizio, Patrizia, Urlaub, Henning, Lührmann, Reinhard, Pena, Vladimir
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343462/
https://ncbi.nlm.nih.gov/pubmed/22407296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.58
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