Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein

The yeast splicing factor Cwc2 contacts several catalytically important RNA elements in the active spliceosome, suggesting that Cwc2 is involved in determining their spatial arrangement at the spliceosome's catalytic centre. We have determined the crystal structure of the Cwc2 functional core,...

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Hlavní autoři: Schmitzová, Jana, Rasche, Nicolas, Dybkov, Olexander, Kramer, Katharina, Fabrizio, Patrizia, Urlaub, Henning, Lührmann, Reinhard, Pena, Vladimir
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343462/
https://ncbi.nlm.nih.gov/pubmed/22407296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.58
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