Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein

The yeast splicing factor Cwc2 contacts several catalytically important RNA elements in the active spliceosome, suggesting that Cwc2 is involved in determining their spatial arrangement at the spliceosome's catalytic centre. We have determined the crystal structure of the Cwc2 functional core,...

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Hauptverfasser: Schmitzová, Jana, Rasche, Nicolas, Dybkov, Olexander, Kramer, Katharina, Fabrizio, Patrizia, Urlaub, Henning, Lührmann, Reinhard, Pena, Vladimir
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343462/
https://ncbi.nlm.nih.gov/pubmed/22407296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.58
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