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Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein

The yeast splicing factor Cwc2 contacts several catalytically important RNA elements in the active spliceosome, suggesting that Cwc2 is involved in determining their spatial arrangement at the spliceosome's catalytic centre. We have determined the crystal structure of the Cwc2 functional core,...

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Bibliografiske detaljer
Main Authors: Schmitzová, Jana, Rasche, Nicolas, Dybkov, Olexander, Kramer, Katharina, Fabrizio, Patrizia, Urlaub, Henning, Lührmann, Reinhard, Pena, Vladimir
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343462/
https://ncbi.nlm.nih.gov/pubmed/22407296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.58
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