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7-Ethynylcoumarins: Selective Inhibitors of Human Cytochrome P450s 1A1 and 1A2
To discover new selective mechanism-based P450 inhibitors, eight 7-ethynylcoumarin derivatives were prepared through a facile two-step synthetic route. Cytochrome P450 activity assays indicated that introduction of functional groups in the backbone of coumarin could enhance the inhibition activities...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358478/ https://ncbi.nlm.nih.gov/pubmed/22443586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300023p |
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