7-Ethynylcoumarins: Selective Inhibitors of Human Cytochrome P450s 1A1 and 1A2

To discover new selective mechanism-based P450 inhibitors, eight 7-ethynylcoumarin derivatives were prepared through a facile two-step synthetic route. Cytochrome P450 activity assays indicated that introduction of functional groups in the backbone of coumarin could enhance the inhibition activities...

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Main Authors: Liu, Jiawang, Nguyen, Thong T., Dupart, Patrick S., Sridhar, Jayalakshmi, Zhang, Xiaoyi, Zhu, Naijue, Stevens, Cheryl L. Klein, Foroozesh, Maryam
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358478/
https://ncbi.nlm.nih.gov/pubmed/22443586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300023p
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