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In Silico Studies of Polyaromatic Hydrocarbon Inhibitors of Cytochrome P450 Enzymes 1A1, 1A2, 2A6, and 2B1

A computational study was undertaken to understand the nature of binding and the structural features that play a significant role in the binding of arylacetylene molecules to cytochrome P450 enzymes 1A1, 1A2, 2A6 and 2B1. Nine polycyclic arylacetylenes determined to be mechanism-based P450 enzyme in...

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Detalhes bibliográficos
Main Authors: Sridhar, Jayalakshmi, Jin, Ping, Liu, Jiawang, Foroozesh, Maryam, Klein Stevens, Cheryl L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839030/
https://ncbi.nlm.nih.gov/pubmed/20078084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900348v
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