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Development of Flavone Propargyl Ethers as Potent and Selective Inhibitors of Cytochrome P450 Enzymes 1A1 and 1A2

Naturally occurring flavonoids are known to be metabolized by several cytochrome P450 enzymes including P450s 1A1, 1A2, 1B1, 2C9, 3A4, and 3A5. In general flavonoids can act as substrates, inducers, and/or inhibitors of P450 enzymes. The position of the substituents on the flavone backbone has been...

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Detaylı Bibliyografya
Asıl Yazarlar: Sridhar, Jayalakshmi, Ellis, Jamie, Dupart, Patrick, Liu, Jiawang, Stevens, Cheryl L., Foroozesh, Maryam
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180220/
https://ncbi.nlm.nih.gov/pubmed/23506553
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