Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrP(res )level disparity

BACKGROUND: Prion disease transmission and pathogenesis are linked to misfolded, typically protease resistant (PrP(res)) conformers of the normal cellular prion protein (PrP(C)), with the former posited to be the principal constituent of the infectious 'prion'. Unexplained discrepancies ob...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lewis, Victoria, Haigh, Cathryn L, Masters, Colin L, Hill, Andrew F, Lawson, Victoria A, Collins, Steven J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2012
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355018/
https://ncbi.nlm.nih.gov/pubmed/22534096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-18
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