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Residues Surrounding the Glycosylphosphatidylinositol Anchor Attachment Site of PrP Modulate Prion Infection: Insight from the Resistance of Rabbits to Prion Disease

Prion diseases are a group of transmissible, invariably fatal neurodegenerative diseases that affect both humans and animals. According to the protein-only hypothesis, the infectious agent is a prion (proteinaceous infectious particle) that is composed primarily of PrP(Sc), the disease-associated is...

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Detalhes bibliográficos
Main Authors: Nisbet, Rebecca M., Harrison, Christopher F., Lawson, Victoria A., Masters, Colin L., Cappai, Roberto, Hill, Andrew F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903296/
https://ncbi.nlm.nih.gov/pubmed/20427543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02709-09
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