Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrP(res )level disparity

BACKGROUND: Prion disease transmission and pathogenesis are linked to misfolded, typically protease resistant (PrP(res)) conformers of the normal cellular prion protein (PrP(C)), with the former posited to be the principal constituent of the infectious 'prion'. Unexplained discrepancies ob...

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Detalhes bibliográficos
Main Authors: Lewis, Victoria, Haigh, Cathryn L, Masters, Colin L, Hill, Andrew F, Lawson, Victoria A, Collins, Steven J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355018/
https://ncbi.nlm.nih.gov/pubmed/22534096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-18
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