Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells

p66Shc, a longevity adaptor protein, is demonstrated as a key regulator of reactive oxygen species (ROS) metabolism involved in aging and cardiovascular diseases. Vascular endothelial growth factor (VEGF) stimulates endothelial cell (EC) migration and proliferation primarily through the VEGF recepto...

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Detalhes bibliográficos
Main Authors: Oshikawa, Jin, Kim, Seok-Jo, Furuta, Eiji, Caliceti, Cristiana, Chen, Gin-Fu, McKinney, Ronald D., Kuhr, Frank, Levitan, Irena, Fukai, Tohru, Ushio-Fukai, Masuko
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Signaling and Stress Response
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353779/
https://ncbi.nlm.nih.gov/pubmed/22101521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00739.2011
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