Extracellular SOD-Derived H(2)O(2) Promotes VEGF Signaling in Caveolae/Lipid Rafts and Post-Ischemic Angiogenesis in Mice

Reactive oxygen species (ROS), in particular, H(2)O(2), is essential for full activation of VEGF receptor2 (VEGFR2) signaling involved in endothelial cell (EC) proliferation and migration. Extracellular superoxide dismutase (ecSOD) is a major secreted extracellular enzyme that catalyzes the dismutat...

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Detalhes bibliográficos
Main Authors: Oshikawa, Jin, Urao, Norifumi, Kim, Ha Won, Kaplan, Nihal, Razvi, Masooma, McKinney, Ronald, Poole, Leslie B., Fukai, Tohru, Ushio-Fukai, Masuko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858087/
https://ncbi.nlm.nih.gov/pubmed/20422004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010189
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