Extracellular SOD-Derived H(2)O(2) Promotes VEGF Signaling in Caveolae/Lipid Rafts and Post-Ischemic Angiogenesis in Mice

Reactive oxygen species (ROS), in particular, H(2)O(2), is essential for full activation of VEGF receptor2 (VEGFR2) signaling involved in endothelial cell (EC) proliferation and migration. Extracellular superoxide dismutase (ecSOD) is a major secreted extracellular enzyme that catalyzes the dismutat...

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Autors principals: Oshikawa, Jin, Urao, Norifumi, Kim, Ha Won, Kaplan, Nihal, Razvi, Masooma, McKinney, Ronald, Poole, Leslie B., Fukai, Tohru, Ushio-Fukai, Masuko
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858087/
https://ncbi.nlm.nih.gov/pubmed/20422004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010189
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