Extracellular SOD-Derived H(2)O(2) Promotes VEGF Signaling in Caveolae/Lipid Rafts and Post-Ischemic Angiogenesis in Mice

Reactive oxygen species (ROS), in particular, H(2)O(2), is essential for full activation of VEGF receptor2 (VEGFR2) signaling involved in endothelial cell (EC) proliferation and migration. Extracellular superoxide dismutase (ecSOD) is a major secreted extracellular enzyme that catalyzes the dismutat...

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Main Authors: Oshikawa, Jin, Urao, Norifumi, Kim, Ha Won, Kaplan, Nihal, Razvi, Masooma, McKinney, Ronald, Poole, Leslie B., Fukai, Tohru, Ushio-Fukai, Masuko
格式: Artigo
語言:Inglês
出版: Public Library of Science 2010
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858087/
https://ncbi.nlm.nih.gov/pubmed/20422004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010189
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