WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway

WNK [with no lysine (K)] kinase is a subfamily of serine/threonine kinases. Mutations in two members of this family (WNK1 and WNK4) cause pseudohypoaldosteronism type II featuring hypertension, hyperkalemia, and metabolic acidosis. WNK1 and WNK4 were shown to regulate sodium chloride cotransporter (...

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Detalhes bibliográficos
Main Authors: Zhou, Bo, Wang, Dexuan, Feng, Xiuyan, Zhang, Yiqian, Wang, Yanhui, Zhuang, Jieqiu, Zhang, Xuemei, Chen, Guangping, Delpire, Eric, Gu, Dingying, Cai, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353643/
https://ncbi.nlm.nih.gov/pubmed/22114204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00032.2011
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