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WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism

WNK [with no lysine (k)] kinase is a serine/threonine kinase subfamily. Mutations in two of the WNK kinases result in pseudohypoaldosteronism type II (PHA II) characterized by hypertension, hyperkalemia, and metabolic acidosis. Recent studies showed that both WNK1 and WNK4 inhibit ROMK activity. How...

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Bibliografiske detaljer
Main Authors: Zhuang, Jieqiu, Zhang, Xuemei, Wang, Dexuan, Li, Juan, Zhou, Bo, Shi, Zhen, Gu, Dingying, Denson, Donald D., Eaton, Douglas C., Cai, Hui
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154587/
https://ncbi.nlm.nih.gov/pubmed/21613417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00518.2010
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