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WNK4 kinase inhibits Maxi K channel activity by a kinase-dependent mechanism
WNK [with no lysine (k)] kinase is a serine/threonine kinase subfamily. Mutations in two of the WNK kinases result in pseudohypoaldosteronism type II (PHA II) characterized by hypertension, hyperkalemia, and metabolic acidosis. Recent studies showed that both WNK1 and WNK4 inhibit ROMK activity. How...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Physiological Society
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3154587/ https://ncbi.nlm.nih.gov/pubmed/21613417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00518.2010 |
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