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WNK4 Enhances the Degradation of NCC through a Sortilin-Mediated Lysosomal Pathway
WNK kinase is a serine/threonine kinase that plays an important role in electrolyte homeostasis. WNK4 significantly inhibits the surface expression of the sodium chloride co-transporter (NCC) by enhancing the degradation of NCC through a lysosomal pathway, but the mechanisms underlying this traffick...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Nephrology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2799281/ https://ncbi.nlm.nih.gov/pubmed/19875813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008121275 |
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