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Characterization of the heparin-binding site of protein Z-dependent protease inhibitor

High molecular weight heparins promote the protein Z-dependent protease inhibitor (ZPI) inhibition of factors Xa (FXa) and XIa (FXIa) by a template mechanism. To map the heparin-binding site of ZPI, the role of basic residues of the D-helix (residues Lys-113, Lys-116, and Lys-125) in the interaction...

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Bibliografiske detaljer
Main Authors: Yang, Likui, Ding, Qiulan, Huang, Xin, Olson, Steven T., Rezaie, Alireza R.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352997/
https://ncbi.nlm.nih.gov/pubmed/22540147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300353c
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