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Characterization of the heparin-binding site of protein Z-dependent protease inhibitor
High molecular weight heparins promote the protein Z-dependent protease inhibitor (ZPI) inhibition of factors Xa (FXa) and XIa (FXIa) by a template mechanism. To map the heparin-binding site of ZPI, the role of basic residues of the D-helix (residues Lys-113, Lys-116, and Lys-125) in the interaction...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3352997/ https://ncbi.nlm.nih.gov/pubmed/22540147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300353c |
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