Heparin Is a Major Activator of the Anticoagulant Serpin, Protein Z-dependent Protease Inhibitor

Protein Z-dependent protease inhibitor (ZPI) is a recently identified member of the serpin superfamily that functions as a cofactor-dependent regulator of blood coagulation factors Xa and XIa. Here we provide evidence that, in addition to the established cofactors, protein Z, lipid, and calcium, hep...

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Bibliographic Details
Main Authors: Huang, Xin, Rezaie, Alireza R., Broze, George J., Olson, Steven T.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058988/
https://ncbi.nlm.nih.gov/pubmed/21220417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.188375
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