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Structural basis for catalytic activation of protein Z–dependent protease inhibitor (ZPI) by protein Z
The anticoagulant serpin, protein Z-dependent protease inhibitor (ZPI), is catalytically activated by its cofactor, protein Z (PZ), to regulate the function of blood coagulation factor Xa on membrane surfaces. The X-ray structure of the ZPI-PZ complex has shown that PZ binds to a unique site on ZPI...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society of Hematology
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3429311/ https://ncbi.nlm.nih.gov/pubmed/22786881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-419598 |
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