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Thermodynamic and Kinetic Characterization of the Protein Z-dependent Protease Inhibitor (ZPI)-Protein Z Interaction Reveals an Unexpected Role for ZPI Lys-239

The anticoagulant serpin, protein Z-dependent protease inhibitor (ZPI), circulates in blood as a tight complex with its cofactor, protein Z (PZ), enabling it to function as a rapid inhibitor of membrane-associated factor Xa. Here, we show that N,N′-dimethyl-N-(acetyl)-N′-(7-nitrobenz-3-oxa-1,3-diazo...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Huang, Xin, Zhou, Jian, Zhou, Aiwu, Olson, Steven T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4392287/
https://ncbi.nlm.nih.gov/pubmed/25713144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.633479
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