Structural basis for catalytic activation of protein Z–dependent protease inhibitor (ZPI) by protein Z

The anticoagulant serpin, protein Z-dependent protease inhibitor (ZPI), is catalytically activated by its cofactor, protein Z (PZ), to regulate the function of blood coagulation factor Xa on membrane surfaces. The X-ray structure of the ZPI-PZ complex has shown that PZ binds to a unique site on ZPI...

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Autores principales: Huang, Xin, Yan, Yahui, Tu, Yizheng, Gatti, Jeffrey, Broze, George J., Zhou, Aiwu, Olson, Steven T.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2012
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3429311/
https://ncbi.nlm.nih.gov/pubmed/22786881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-419598
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