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Identification of Factor Xa Residues Critical for Interaction with Protein Z-dependent Protease Inhibitor: Both Active-site and Exosite Interactions Are Required for Inhibition
Protein Z-dependent protease inhibitor (ZPI) is a plasma serpin which can rapidly inactivate factor Xa (fXa) in the presence of protein Z (PZ), negatively charged phospholipids and Ca(2+). To investigate the mechanism by which ZPI inactivates fXa, we expressed the serpin in mammalian cells and chara...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2005
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1266280/ https://ncbi.nlm.nih.gov/pubmed/16079143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M505517200 |
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