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Identification of Factor Xa Residues Critical for Interaction with Protein Z-dependent Protease Inhibitor: Both Active-site and Exosite Interactions Are Required for Inhibition

Protein Z-dependent protease inhibitor (ZPI) is a plasma serpin which can rapidly inactivate factor Xa (fXa) in the presence of protein Z (PZ), negatively charged phospholipids and Ca(2+). To investigate the mechanism by which ZPI inactivates fXa, we expressed the serpin in mammalian cells and chara...

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Main Authors: Rezaie, Alireza R., Manithody, Chandrashekhara, Yang, Likui
格式: Artigo
語言:Inglês
出版: 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1266280/
https://ncbi.nlm.nih.gov/pubmed/16079143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M505517200
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