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Contribution of Exosite Occupancy by Heparin to the Regulation of Coagulation Proteases by Antithrombin
Heparin promotes the antithrombin (AT) inactivation of factors IXa (fIXa) and Xa (fXa) through a conformational activation of the serpin and also by a template mechanism in the presence of physiological levels of Ca(2+). Recently, it was reported that heparin induces conformational changes in the ac...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818343/ https://ncbi.nlm.nih.gov/pubmed/20024502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH09-08-0585 |
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