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Role of P2 Glycine in Determining the Specificity of Antithrombin Reaction with Coagulation Proteases

Structural data suggests that bulky hydrophobic residues at the S2-S4 sub-sites of factor Xa (fXa) restrict the preference of this pocket for small and non-polar residues like Gly at the P2 position of substrates and inhibitors. However, kinetic studies monitoring the cleavage specificity of 10-resi...

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Autori principali: Yang, Likui, Qureshi, Shabir H., Manithody, Chandrashekhara, Rezaie, Alireza R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750881/
https://ncbi.nlm.nih.gov/pubmed/19715676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.08.118
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