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Role of P2 Glycine in Determining the Specificity of Antithrombin Reaction with Coagulation Proteases
Structural data suggests that bulky hydrophobic residues at the S2-S4 sub-sites of factor Xa (fXa) restrict the preference of this pocket for small and non-polar residues like Gly at the P2 position of substrates and inhibitors. However, kinetic studies monitoring the cleavage specificity of 10-resi...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2750881/ https://ncbi.nlm.nih.gov/pubmed/19715676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.08.118 |
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