The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory Agency Approved Drug

Transthyretin (TTR) is one of the many proteins that are known to misfold and aggregate (i.e., undergo amyloidogenesis) in vivo. The process of TTR amyloidogenesis causes nervous system and/or heart pathology. While several of these maladies are associated with mutations that destabilize the TTR nat...

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書誌詳細
主要な著者: Johnson, Steven M., Connelly, Stephen, Fearns, Colleen, Powers, Evan T., Kelly, Jeffery W.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350832/
https://ncbi.nlm.nih.gov/pubmed/22244854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.060
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