The Importance of a Gatekeeper Residue on the Aggregation of Transthyretin: IMPLICATIONS FOR TRANSTHYRETIN-RELATED AMYLOIDOSES

Protein aggregation into β-sheet-enriched amyloid fibrils is associated with an increasing number of human disorders. The adoption of such amyloid conformations seems to constitute a generic property of polypeptide chains. Therefore, during evolution, proteins have adopted negative design strategies...

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Hlavní autoři: Sant'Anna, Ricardo, Braga, Carolina, Varejão, Nathalia, Pimenta, Karinne M., Graña-Montes, Ricardo, Alves, Aline, Cortines, Juliana, Cordeiro, Yraima, Ventura, Salvador, Foguel, Debora
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192486/
https://ncbi.nlm.nih.gov/pubmed/25086037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.563981
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