The Importance of a Gatekeeper Residue on the Aggregation of Transthyretin: IMPLICATIONS FOR TRANSTHYRETIN-RELATED AMYLOIDOSES

Protein aggregation into β-sheet-enriched amyloid fibrils is associated with an increasing number of human disorders. The adoption of such amyloid conformations seems to constitute a generic property of polypeptide chains. Therefore, during evolution, proteins have adopted negative design strategies...

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Main Authors: Sant'Anna, Ricardo, Braga, Carolina, Varejão, Nathalia, Pimenta, Karinne M., Graña-Montes, Ricardo, Alves, Aline, Cortines, Juliana, Cordeiro, Yraima, Ventura, Salvador, Foguel, Debora
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Molecular Bases of Disease
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192486/
https://ncbi.nlm.nih.gov/pubmed/25086037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.563981
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