The Transthyretin Amyloidoses: From Delineating the Molecular Mechanism of Aggregation Linked to Pathology to a Regulatory Agency Approved Drug

Transthyretin (TTR) is one of the many proteins that are known to misfold and aggregate (i.e., undergo amyloidogenesis) in vivo. The process of TTR amyloidogenesis causes nervous system and/or heart pathology. While several of these maladies are associated with mutations that destabilize the TTR nat...

Full description

Saved in:
Bibliographic Details
Main Authors: Johnson, Steven M., Connelly, Stephen, Fearns, Colleen, Powers, Evan T., Kelly, Jeffery W.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350832/
https://ncbi.nlm.nih.gov/pubmed/22244854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.060
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items