Initial Testing (Stage 1) of the Cyclin Dependent Kinase Inhibitor SCH 727965 (Dinaciclib) by the Pediatric Preclinical Testing Program

BACKGROUND: SCH 727965 is a novel drug in clinical development that potently and selectively inhibits CDK1, CDK2, CDK5, and CDK9. The activity of SCH 727965 was evaluated against the PPTP’s in vitro and in vivo panels. PROCEDURES: SCH 727965 was tested against the PPTP in vitro panel using 96 hour e...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gorlick, Richard, Kolb, E. Anders, Houghton, Peter J., Morton, Christopher L., Neale, Geoffrey, Keir, Stephen T., Carol, Hernan, Lock, Richard, Phelps, Doris, Kang, Min H., Reynolds, C. Patrick, Maris, John M., Billups, Catherine, Smith, Malcolm A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349821/
https://ncbi.nlm.nih.gov/pubmed/22315240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24073
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