Initial Testing (Stage 1) of the Cyclin Dependent Kinase Inhibitor SCH 727965 (Dinaciclib) by the Pediatric Preclinical Testing Program

BACKGROUND: SCH 727965 is a novel drug in clinical development that potently and selectively inhibits CDK1, CDK2, CDK5, and CDK9. The activity of SCH 727965 was evaluated against the PPTP’s in vitro and in vivo panels. PROCEDURES: SCH 727965 was tested against the PPTP in vitro panel using 96 hour e...

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Bibliografische gegevens
Hoofdauteurs: Gorlick, Richard, Kolb, E. Anders, Houghton, Peter J., Morton, Christopher L., Neale, Geoffrey, Keir, Stephen T., Carol, Hernan, Lock, Richard, Phelps, Doris, Kang, Min H., Reynolds, C. Patrick, Maris, John M., Billups, Catherine, Smith, Malcolm A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349821/
https://ncbi.nlm.nih.gov/pubmed/22315240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24073
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