Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival

BACKGROUND: The current treatment regimen for glioma patients is surgery, followed by radiation therapy plus temozolomide (TMZ), followed by 6 months of adjuvant TMZ. Despite this aggressive treatment regimen, the overall survival of all surgically treated GBM patients remains dismal, and additional...

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Bibliografiske detaljer
Main Authors: Schultz, Chad R, Golembieski, William A, King, Daniel A, Brown, Stephen L, Brodie, Chaya, Rempel, Sandra A
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349587/
https://ncbi.nlm.nih.gov/pubmed/22480225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-20
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