Growth Hormone and IGF-1 Deficiency Exacerbate High-Fat Diet–Induced Endothelial Impairment in Obese Lewis Dwarf Rats: Implications for Vascular Aging

Previous studies suggest that the age-related decline in circulating growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels significantly contribute to vascular dysfunction in aging by impairing cellular oxidative stress resistance pathways. Obesity in elderly individuals is increasing...

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Main Authors: Bailey-Downs, Lora C., Sosnowska, Danuta, Toth, Peter, Mitschelen, Matthew, Gautam, Tripti, Henthorn, Jim C., Ballabh, Praveen, Koller, Akos, Farley, Julie A., Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Journal of Gerontology: BIOLOGICAL SCIENCES
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348491/
https://ncbi.nlm.nih.gov/pubmed/22080499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glr197
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