Liver-Specific Knockdown of IGF-1 Decreases Vascular Oxidative Stress Resistance by Impairing the Nrf2-Dependent Antioxidant Response: A Novel Model of Vascular Aging

Recent studies demonstrate that age-related dysfunction of NF-E2–related factor-2 (Nrf2)–driven pathways impairs cellular redox homeostasis, exacerbating age-related cellular oxidative stress and increasing sensitivity of aged vessels to oxidative stress–induced cellular damage. Circulating levels o...

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Hlavní autoři: Bailey-Downs, Lora C., Mitschelen, Matthew, Sosnowska, Danuta, Toth, Peter, Pinto, John T., Ballabh, Praveen, Valcarcel-Ares, M.Noa, Farley, Julie, Koller, Akos, Henthorn, Jim C., Bass, Caroline, Sonntag, William E., Ungvari, Zoltan, Csiszar, Anna
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Journal of Gerontology: BIOLOGICAL SCIENCES
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309870/
https://ncbi.nlm.nih.gov/pubmed/22021391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glr164
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