Disruption of Nrf2 Signaling Impairs Angiogenic Capacity of Endothelial Cells: Implications for Microvascular Aging

The redox-sensitive transcription factor NF-E2–related factor 2 (Nrf2) plays a key role in preserving a healthy endothelial phenotype and maintaining the functional integrity of the vasculature. Previous studies demonstrated that aging is associated with Nrf2 dysfunction in endothelial cells, which...

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Detalhes bibliográficos
Main Authors: Valcarcel-Ares, M. Noa, Gautam, Tripti, Warrington, Junie P., Bailey-Downs, Lora, Sosnowska, Danuta, de Cabo, Rafael, Losonczy, Gyorgy, Sonntag, William E., Ungvari, Zoltan, Csiszar, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Journal of Gerontology: BIOLOGICAL SCIENCES
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403863/
https://ncbi.nlm.nih.gov/pubmed/22219515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glr229
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