Age-Associated Vascular Oxidative Stress, Nrf2 Dysfunction, and NF-κB Activation in the Nonhuman Primate Macaca mulatta

Aging promotes oxidative stress in vascular endothelial and smooth muscle cells, which contribute to the development of cardiovascular diseases. NF-E2–related factor 2 (Nrf2) is a transcription factor, which is activated by reactive oxygen species in the vasculature of young animals, leading to adap...

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Bibliographic Details
Main Authors: Ungvari, Zoltan, Bailey-Downs, Lora, Gautam, Tripti, Sosnowska, Danuta, Wang, Mingyi, Monticone, Robert E., Telljohann, Richard, Pinto, John T., de Cabo, Raphael, Sonntag, William E., Lakatta, Edward G., Csiszar, Anna
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Journal of Gerontology: BIOLOGICAL SCIENCES
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148762/
https://ncbi.nlm.nih.gov/pubmed/21622983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glr092
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