Ionizing Radiation Promotes the Acquisition of a Senescence-Associated Secretory Phenotype and Impairs Angiogenic Capacity in Cerebromicrovascular Endothelial Cells: Role of Increased DNA Damage and Decreased DNA Repair Capacity in Microvascular Radiosensitivity

Cerebromicrovascular rarefaction is believed to play a central role in cognitive impairment in patients receiving whole-brain irradiation therapy. To elucidate the mechanism underlying the deleterious effects of γ-irradiation on the cerebral microcirculation, rat primary cerebromicrovascular endothe...

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Main Authors: Ungvari, Zoltan, Podlutsky, Andrej, Sosnowska, Danuta, Tucsek, Zsuzsanna, Toth, Peter, Deak, Ferenc, Gautam, Tripti, Csiszar, Anna, Sonntag, William E.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814240/
https://ncbi.nlm.nih.gov/pubmed/23689827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glt057
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