Age-Related Decline of Autocrine Pituitary Adenylate Cyclase-Activating Polypeptide Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells

Aging impairs angiogenic capacity of cerebromicrovascular endothelial cells (CMVECs) promoting microvascular rarefaction, but the underlying mechanisms remain elusive. PACAP is an evolutionarily conserved neuropeptide secreted by endothelial cells and neurons, which confers important antiaging effec...

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Detalhes bibliográficos
Publicado no:J Gerontol A Biol Sci Med Sci
Main Authors: Banki, Eszter, Sosnowska, Danuta, Tucsek, Zsuzsanna, Gautam, Tripti, Toth, Peter, Tarantini, Stefano, Tamas, Andrea, Helyes, Zsuzsanna, Reglodi, Dora, Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447801/
https://ncbi.nlm.nih.gov/pubmed/25136000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glu116
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