Age-Related Decline of Autocrine Pituitary Adenylate Cyclase-Activating Polypeptide Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells

Aging impairs angiogenic capacity of cerebromicrovascular endothelial cells (CMVECs) promoting microvascular rarefaction, but the underlying mechanisms remain elusive. PACAP is an evolutionarily conserved neuropeptide secreted by endothelial cells and neurons, which confers important antiaging effec...

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Pubblicato in:J Gerontol A Biol Sci Med Sci
Autori principali: Banki, Eszter, Sosnowska, Danuta, Tucsek, Zsuzsanna, Gautam, Tripti, Toth, Peter, Tarantini, Stefano, Tamas, Andrea, Helyes, Zsuzsanna, Reglodi, Dora, Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447801/
https://ncbi.nlm.nih.gov/pubmed/25136000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glu116
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