The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα

The thiosemicarbazones Dp44mT (di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone) and triapine have potent antiproliferative activity and have been evaluated as anticancer agents. While these compounds strongly bind iron and copper, their mechanism(s) of action are incompletely understood. A recen...

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Hlavní autoři: Yalowich, Jack C., Wu, Xing, Zhang, Rui, Kanagasabai, Ragu, Hornbaker, Marissa, Hasinoff, Brian B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348365/
https://ncbi.nlm.nih.gov/pubmed/22503743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.03.021
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