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Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts
Retroviral vectors integrate in genes and regulatory elements and may cause transcriptional deregulation of gene expression in target cells. Integration into transcribed genes also has the potential to deregulate gene expression at the posttranscriptional level by interfering with splicing and polya...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3347495/ https://ncbi.nlm.nih.gov/pubmed/22523069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61852 |
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