Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts

Retroviral vectors integrate in genes and regulatory elements and may cause transcriptional deregulation of gene expression in target cells. Integration into transcribed genes also has the potential to deregulate gene expression at the posttranscriptional level by interfering with splicing and polya...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Moiani, Arianna, Paleari, Ylenia, Sartori, Daniela, Mezzadra, Riccardo, Miccio, Annarita, Cattoglio, Claudia, Cocchiarella, Fabienne, Lidonnici, Maria Rosa, Ferrari, Giuliana, Mavilio, Fulvio
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2012
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347495/
https://ncbi.nlm.nih.gov/pubmed/22523069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61852
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