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Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations
Gamma-retroviral/lentiviral vectors (γRV/LV) with self-inactivating (SIN) long terminal repeats (LTRs) and internal moderate cellular promoters pose a reduced risk of insertional mutagenesis when compared with vectors with active LTRs. Yet, in a recent LV-based clinical trial for β-thalassemia, vect...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3336994/ https://ncbi.nlm.nih.gov/pubmed/22523064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI62189 |
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