Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations

Gamma-retroviral/lentiviral vectors (γRV/LV) with self-inactivating (SIN) long terminal repeats (LTRs) and internal moderate cellular promoters pose a reduced risk of insertional mutagenesis when compared with vectors with active LTRs. Yet, in a recent LV-based clinical trial for β-thalassemia, vect...

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Autori principali: Cesana, Daniela, Sgualdino, Jacopo, Rudilosso, Laura, Merella, Stefania, Naldini, Luigi, Montini, Eugenio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336994/
https://ncbi.nlm.nih.gov/pubmed/22523064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI62189
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