Uncovering and Dissecting the Genotoxicity of Self-inactivating Lentiviral Vectors In Vivo

Self-inactivating (SIN) lentiviral vectors (LV) have an excellent therapeutic potential as demonstrated in preclinical studies and clinical trials. However, weaker mechanisms of insertional mutagenesis could still pose a significant risk in clinical applications. Taking advantage of novel in vivo ge...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Cesana, Daniela, Ranzani, Marco, Volpin, Monica, Bartholomae, Cynthia, Duros, Caroline, Artus, Alexandre, Merella, Stefania, Benedicenti, Fabrizio, Sergi Sergi, Lucia, Sanvito, Francesca, Brombin, Chiara, Nonis, Alessandro, Serio, Clelia Di, Doglioni, Claudio, von Kalle, Christof, Schmidt, Manfred, Cohen-Haguenauer, Odile, Naldini, Luigi, Montini, Eugenio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
Schlagworte:
Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982501/
https://ncbi.nlm.nih.gov/pubmed/24441399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.3
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge