Uncovering and Dissecting the Genotoxicity of Self-inactivating Lentiviral Vectors In Vivo

Self-inactivating (SIN) lentiviral vectors (LV) have an excellent therapeutic potential as demonstrated in preclinical studies and clinical trials. However, weaker mechanisms of insertional mutagenesis could still pose a significant risk in clinical applications. Taking advantage of novel in vivo ge...

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Detalles Bibliográficos
Autores principales: Cesana, Daniela, Ranzani, Marco, Volpin, Monica, Bartholomae, Cynthia, Duros, Caroline, Artus, Alexandre, Merella, Stefania, Benedicenti, Fabrizio, Sergi Sergi, Lucia, Sanvito, Francesca, Brombin, Chiara, Nonis, Alessandro, Serio, Clelia Di, Doglioni, Claudio, von Kalle, Christof, Schmidt, Manfred, Cohen-Haguenauer, Odile, Naldini, Luigi, Montini, Eugenio
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982501/
https://ncbi.nlm.nih.gov/pubmed/24441399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.3
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