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Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts
Retroviral vectors integrate in genes and regulatory elements and may cause transcriptional deregulation of gene expression in target cells. Integration into transcribed genes also has the potential to deregulate gene expression at the posttranscriptional level by interfering with splicing and polya...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3347495/ https://ncbi.nlm.nih.gov/pubmed/22523069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI61852 |
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