Deletion of the LTR Enhancer/Promoter Has No Impact on the Integration Profile of MLV Vectors in Human Hematopoietic Progenitors

Moloney murine leukemia virus (MLV)-derived gamma-retroviral vectors integrate preferentially near transcriptional regulatory regions in the human genome, and are associated with a significant risk of insertional gene deregulation. Self-inactivating (SIN) vectors carry a deletion of the U3 enhancer...

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Main Authors: Moiani, Arianna, Miccio, Annarita, Rizzi, Ermanno, Severgnini, Marco, Pellin, Danilo, Suerth, Julia Debora, Baum, Christopher, De Bellis, Gianluca, Mavilio, Fulvio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561312/
https://ncbi.nlm.nih.gov/pubmed/23383272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055721
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