UCLA1, a Synthetic Derivative of a gp120 RNA Aptamer, Inhibits Entry of Human Immunodeficiency Virus Type 1 Subtype C

Entry of human immunodeficiency virus type 1 (HIV-1) into cells is mediated by the virion surface envelope (Env) glycoproteins, making it a desirable target for antiretroviral entry inhibitors. We previously isolated a family of gp120 binding RNA aptamers and showed that they neutralized the infecti...

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Autori principali: Mufhandu, Hazel T., Gray, Elin S., Madiga, Maphuti C., Tumba, Nancy, Alexandre, Kabamba B., Khoza, Thandeka, Wibmer, Constantinos Kurt, Moore, Penny L., Morris, Lynn, Khati, Makobetsa
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3347371/
https://ncbi.nlm.nih.gov/pubmed/22379083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06893-11
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