UCLA1 aptamer inhibition of human immunodeficiency virus type 1 subtype C primary isolates in macrophages and selection of resistance

We have previously shown that the aptamer, UCLA1, is able to inhibit HIV-1 replication in peripheral blood mononuclear cells (PBMCs) by binding to residues in gp120. In this study we examined whether UCLA1 was effective against HIV-1 subtype C isolates in monocyte-derived macrophages (MDMs). Of 4 ma...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Rep
Main Authors: Mufhandu, Hazel Tumelo, Alexandre, Kabamba Bankoledi, Gray, Elin Solomonovna, Morris, Lynn, Khati, Makobetsa
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5613508/
https://ncbi.nlm.nih.gov/pubmed/28955932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2016.07.005
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