An Aptamer That Neutralizes R5 Strains of Human Immunodeficiency Virus Type 1 Blocks gp120-CCR5 Interaction

We recently described the isolation and structural characterization of 2′-fluoropyrimidine-substituted RNA aptamers that bind to gp120 of R5 strains of human immunodeficiency virus type 1 and thereby potently neutralize the infectivity of phylogenetically diverse R5 strains. Here we investigate the...

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Autori principali: Dey, Antu K., Khati, Makobetsa, Tang, Min, Wyatt, Richard, Lea, Susan M., James, William
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1262572/
https://ncbi.nlm.nih.gov/pubmed/16227301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.21.13806-13810.2005
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